timp1 (R&D Systems)

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R&D Systems timp1
Timp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+human+timp+1/Recombinant+Human+TIMP-1+Protein%2C+CF/pmc12065878-379-153-154
Average 93 stars, based on 46 article reviews

timp1 - by Bioz Stars, 2026-10

93/100 stars

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Article Title: TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy.
Article Snippet: Temporal lobe epilepsy is frequently associated with granule cell dispersion (GCD), an abnormal widening of the granule cell layer in the dentate gyrus.. There is increasing evidence that a loss and the functional inactivation of the positional signal Reelin is involved in GCD formation.. Reelin is synthesized and released by Cajal-Retzius cells and interneurons, and its function depends on proteolytic cleavage after secretion.

Article Title: TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity.
Article Snippet: .. However, an additional endotoxin-negative control was performed using a heterologous recombinant human TIMP-1 (R&D Systems, Minneapolis, Genes & Immunity MN, USA, #970-TM). .. After 24 h incubation with the recombinant proteins, the BMDCs were harvested, washed with PBS, centrifuged at 1000 rpm for 5minutes, and stained for immunophenotyping studies using flow cytometry, or lysed using lysis buffer [17] (Cell Signaling Technology, Danvers, MA, USA) to be used for cell signaling assays using Western blot.

Article Title: Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8
Article Snippet: Digests were subjected to reducing SDS-PAGE and immunoblotting with rabbit polyclonal anti-OPN antibody (Abcam, Cat. n.: Ab8448, 95 μg/ml). .. Where indicated, 1 μM recombinant human TIMP-1, -2, -3, or -4 (R&D Systems, Cat. n.: 970-TM, 971-TM, 973-TM, 974-TSF) were preincubated with 500 nM ADAMTS8 for 1 h at 37 °C before digestion. .. Bands were detected with a Chemidoc Touch Imaging system (Bio-Rad), and intensities were measured using Image lab software version 5.2.1.

Article Title: Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells.
Article Snippet: http://dx.doi.org/10.1016/j.pep.2014.06.013 1046-5928/ 2014 Elsevier Inc. All rights reserved.. ⇑ Corresponding author.. Address: Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, c/o Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

Article Title: The metalloproteinase ADAM10 requires its activity to sustain surface expression
Article Snippet: TAPI-1 was from Merck (Darmstadt, Germany). .. NH 4 Cl and saponin were from Carl Roth (Karlsruhe, Germany), monensin was from Tocris Bioscience (Bristol, UK), cycloheximide, ionomycin, and bafilomycin A1 were from Sigma-Aldrich (St. Louis, USA), ikarugamycin was from biomol (Hamburg, Germany), recombinant human TIMP-1 (970-TM-010) was from R&D Systems (Minneapolis, USA), E. coli pHrodo (P35366), EZ-LinkTM Sulfo-NHS-LC-Biotin, and Aldehyde/Sulfate latex beads were from Thermo Fisher Scientific (Waltham, USA), Streptavidin-Sepharose High Performance was from GE Healthcare (Chicago, USA) and the ADAM10 substrate peptide (PRYEAYKMG) was from peptides & elephants (Hennigsdorf, Germany). .. The human monocytic leukemia cell line THP-1 was cultured in RPMI medium with 10% FCS (PanBiotech, Aidenbach, Germany) and 1% penicillin–streptomycin (Sigma-Aldrich, St. Louis, USA).

Article Title: TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity
Article Snippet: .. However, an additional endotoxin-negative control was performed using a heterologous recombinant human TIMP-1 (R&D Systems, Minneapolis, MN, USA, #970-TM). .. After 24 h incubation with the recombinant proteins, the BMDCs were harvested, washed with PBS, centrifuged at 1000 rpm for 5 minutes, and stained for immunophenotyping studies using flow cytometry, or lysed using lysis buffer [ ] (Cell Signaling Technology, Danvers, MA, USA) to be used for cell signaling assays using Western blot.

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Article Title: Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells.
Article Snippet: http://dx.doi.org/10.1016/j.pep.2014.06.013 1046-5928/ 2014 Elsevier Inc. ⇑ Corresponding author.. Address: Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, c/o Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

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